Bone Morphogenetic Proteins: A Realistic Alternative to Bone Grafting for Alveolar Reconstruction
Preclinical studies have shown that rhBMP-2 induces normal physiologic bone in clinically relevant defects in the craniofacial skeleton. The newly formed bone assumes characteristics of the adjacent resident bone and allows placement, osseointegration/re-osseointegration, and functional loading of endosseous implants. Clinical studies optimizing dose, delivery technologies, and conditions for stimulation of bone growth will bring about a new era in dentistry. The ability to predictably promote osteogenesis through the use of bone morphogenetic protein technologies is not far from becoming a clinical reality and will have an astounding effect on how dentistry is practiced.
Laboratory for Applied Periodontal & Craniofacial Regeneration, Medical College of Georgia School of Dentistry AD1430, 1120 15th Street, Augusta, GA 30912, USA
Corresponding author.
Earlier versions of this text have been published for reviews in journals and book chapters. The text is continuously subject to revisions and updating as new information becomes available in our laboratory. The Laboratory for Applied Periodontal & Craniofacial Regeneration is supported in part by a grant from Nobel Biocare AB, Sweden.
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