Advances in Diagnosis and Management of Fibro-Osseous Lesions

Fibro-osseous lesions are benign mesenchymal skeletal tumors in which mineralized tissue, blood vessels, and giant cells in varying proportions replace normal bone. Included in this group are fibrous dysplasia, cherubism, ossifying fibromas, and osteoblastoma, with fibrous dysplasia being the most common entity. Although fibro-osseous lesions have similar histologic and radiographic features, they may exhibit a wide range of biologic behaviors. Because the histologic appearance does not predict the rate of growth or prognosis, treatment is based on the clinical and biologic behavior of the tumor. The purpose of this article is to describe advances in diagnosis and management of fibro-osseous lesions.